教員・研究者教員・研究紹介

福森良（ふくもりりょう）助教

所属

薬学部薬学科

専門分野

薬理学、分子薬理学

研究テーマ

グルタミン酸神経毒性関連疾患の神経精神薬理学

担当科目

薬理学実習、基本科学実習

所属学会

日本薬理学会、日本神経精神薬理学会、日本薬学会、日本神経化学会

研究室

薬学棟L101号室（薬理学）

連絡先

TEL:0956-20-5611（薬学事務室）　FAX:0956-20-5622

E-mail

fukumori

URL

－

プロフィール

2008年金沢大学大学院自然科学研究科博士前期課程入学
2010年金沢大学大学院自然科学研究科博士前期課程修了
2010年金沢大学大学院自然科学研究科博士後期課程入学
2013年金沢大学大学院自然科学研究科博士後期課程修了
2013年長崎国際大学薬学部薬理学研究室助教現職

研究活動

受賞

福森良, 第49回日本神経精神薬理学会一般演題奨励賞, 日本神経精神薬理学会, 2019

福森良, 日本薬学会北陸支部第122回例会大学院優秀発表賞, 日本薬学会北陸支部, 2010

Ryo Fukumori., JSNP Excellent Presentation Award for CINP 2010., 日本神経精神薬理学会, 2010

Ryo Fukumori., International Society for Neurochemistry Travel Awards., International Society for Neurochemistry, 2009

研究実績

著書

山本経之、山口拓、福森良, 大麻・フィトカンナピノイドの有害性と医薬品としての応用：
基礎と臨床, 大麻問題の現状, 18-32, 2020

宝田剛志、福森良、米田幸雄, グルタミン酸神経毒性とミトコンドリア因子, 脳. 21. 17, 106-110, 2014

論文

Ren-shi Li, Ryo Fukumori, Tomoki Takeda, Yingxia Song, Satoshi Morimoto, Ruri Kikura-Hanajiri, Taku Yamaguchi, Kazuhito Watanabe, Kousuke Aritake, Yoshitaka Tanaka, Hideyuki Yamada, Tsuneyuki Yamamoto, Yuji Ishii., Elevation of endocannabinoids in the brain by synthetic cannabinoid JWH-018: mechanism and effect on learning and memory. Sci Rep. 3;9(1):9621., 2019

Yoko Nawata, Taku Yamaguchi, Ryo Fukumori, Tsuneyuki Yamamoto., Inhibition of Monoacylglycerol Lipase Reducesthe Reinstatement of Methamphetamine-Seeking　and Anxiety-Like Behaviors in Methamphetamine　Self-Administered Rats., International Journal of Neuropsychopharmacology. 1;22(2):165-172., 2019

Koichi Fujikawa, Ryo Fukumori, Saki Nakamura, Tetsuo Kutsukake, Takeshi Takarada, Yukio Yoneda., Potential interactions of calcium-sensitive reagents with zinc ion in different cultured cells., PLoS ONE. e0127421., 2015

Ryo Fukumori*, Takeshi Takarada*, Ryota Nakazato, Koichi Fujikawa, Miki Kou, Eiichi Hinoi and Yukio Yoneda (2013) Selective inhibition by ethanol of mitochondrial calcium influx mediated by uncoupling protein-2 in relation to N-methyl-D-aspartate cytotoxicity in cultured neurons. PLoS ONE. 8, e69718. *Equally contributed.

Takeshi Takarada*, Miki Kou*, Noritaka Nakamichi, Masato Ogura, Yuma Ito, Ryo Fukumori, Hiroshi Kokubo, Gabriela B. Acosta, Eiichi Hinoi and Yukio Yoneda (2013) Myosin VI reduces proliferation, but not differentiation, in pluripotent P19 cells. PLoS ONE. 8, e63947. *Equally contributed.

Masato Ogura*, Takami Kakuda*, Takeshi Takarada*, Noritaka Nakamichi, Ryo Fukumori, Yeong-Hun Kim, Eiichi Hinoi and Yukio Yoneda (2012) Promotion of both proliferation and differentiation in pluripotent P19 cells with stable overexpression of the glutamine transporter Slc38a1. PLoS ONE. 7, e48270. *Equally contributed.

Takeshi Takarada*, Noritaka Nakamichi*, Seiya Kitajima, Ryo Fukumori, Ryota Nakazato, Nguyen Quynh Le, Yeong-Hun Kim, Koichi Fujikawa, Miki Kou and Yukio Yoneda (2012) Promoted neuronal differentiation after activation of alpha4/beta2 nicotinic acetylcholine receptors in undifferentiated neural progenitors. PLoS ONE. 7, e46177. *Equally contributed.

Takeshi Takarada*, Noritaka Nakamichi*, Hirofumi Kawagoe, Masato Ogura, Ryo Fukumori, Ryota Nakazato, Koichi Fujikawa, Miki Kou and Yukio Yoneda (2012) Possible neuroprotective property of nicotinic acetylcholine receptors in association with predominant upregulation of glial cell line-derived neurotrophic factor in astrocytes. J Neurosci Res. 90, 2074-2085. *Equally contributed.

Ryo Fukumori*, Takeshi Takarada*, Yuki Kambe, Ryota Nakazato, Koichi Fujikawa and Yukio Yoneda (2012) Possible involvement of mitochondrial uncoupling protein-2 in cytotoxicity mediated by acquired N-methyl-D-aspartate receptor channels. Neurochem Int. in press. *Equally contributed.

Koichi Fujikawa*, Noritaka Nakamichi*, Shunsuke Kato, Ryo Fukumori, Miho Hida, Takeshi Takarada and Yukio Yoneda (2012) Delayed mitochondrial membrane potential disruption by ATP in cultured rat hippocampal neurons exposed to N-methyl-D-aspartate. J Pharmacol Sci.. in press. *Equally contributed.

Takahisa Gono*, Takeshi Takarada*, Ryo Fukumori, Yasushi Kawaguchi, Hirotaka Kaneko, Masanori Hanaoka, Yasuhiro Katsumata, Yukio Yoneda and Hisashi Yamanaka (2011) NR2-reactive antibody decreases cell viability through augmentation of Ca2+ influx in systemic lupus erythematosus. Arthritis Rheum. 63, 3952-3959. *Equally contributed.

Yuki Kambe, Noritaka Nakamichi, Takeshi Takarada, Ryo Fukumori, Ryota Nakazato, Eiichi Hinoi and Yukio Yoneda (2011) A pivotal role of mitochondrial free calcium in neurotoxicity mediated by N-methyl-D-aspartate receptors in cultured rat hippocampal neurons. Neurochem Int. 59, 10-20.

Ryo Fukumori, Takeshi Takarada, Noritaka Nakamichi, Yuki Kambe, Hirofumi Kawagoe, Ryota Nakazato and Yukio Yoneda (2010) Requirement of both NR3A and NR3B subunits for dominant negative properties on Ca2+ mobilization mediated by acquired N-methyl-D-aspartate receptor channels into mitochondria. Neurochem Int . 57, 730-737.

Noritaka Nakamichi*, Ryo Fukumori*, Takeshi Takarada, Yuki Kambe, Tomomi Yamamoto, Nobuyuki Matsushima, Nobuaki Moriguchi and Yukio Yoneda (2010) Preferential inhibition by antidiarrheic 2-methoxy-4-methylphenol of Ca2+ influx across acquired N-methyl-D-aspartate receptor channels composed of NR1/NR2B subunit assembly. J Neurosci Res. 88, 2483-2493.*Equal contribution.

Yuki Kambe, Noritaka Nakamichi, Takeshi Takarada, Ryo Fukumori and Yukio Yoneda (2010) Induced tolerance to glutamate neurotoxicity through downregulation of NR2 subunits of N-methyl-D-aspartate receptors in cultured rat striatal neurons. J Neurosci Res. 88, 2177-2187.

Ryo Fukumori*, Noritaka Nakamichi*, Takeshi Takarada, Yuki Kambe, Nobuyuki Matsushima, Nobuaki Moriguchi and Yukio Yoneda (2010) Inhibition by 2-methoxy-4-ethylphenol of Ca2+ influx through acquired and native N-methyl-D-aspartate receptor channels. J Pharmacol Sci. 112, 273-281. *Equal contribution.

Bin Gu*, Noritaka Nakamichi*, Wen-Sheng Zhang, Yukary Nakamura, Yuki Kambe, Ryo Fukumori, Kazuhiro Takuma, Kiyofumi Yamada, Takeshi Takarada, Hideo Taniura and Yukio Yoneda (2009) Possible protection by notoginsenoside R1 against neurotoxicity of N-methyl-D-aspartate receptor composed of an NR1/NR2B heteromeric assembly. J Neurosci Res. 87, 2145-2156. *Equally contributed.

学会発表・シンポジウム・講演

＜国際学会発表（筆頭発表者のみ、他10報）＞

Ryo Fukumori, Satoshi Yamada, Taku Yamaguchi and Tsuneyuki Yamamoto., Involvement of cannabinoid CB1 receptors on impairment of prepulse inhibition during withdrawal state after the repeated administration of methamphetamine in mice., The 18th World Congress of Basic and Clinical Pharmacology (WCP2018), Kyoto, 7/1-6, 2018

Ryo Fukumori, Satoshi Yamada, Taku Yamaguchi and Tsuneyuki Yamamoto., Possible involvement of cannabinoid CB1 receptors in behavioral impairments after withdrawal from chronic methamphetamine administration in mice., The 30th CINP World Congress of neuropsychopharmacology., Seoul, 7/3-5, 2016

Ryo Fukumori, Satoshi Yamada, Taku Yamaguchi and Tsuneyuki Yamamoto., Involvement of endocannabinoid system on cognitive dysfunction during withdrawal of repeated methamphetamine administration in mice., Neuroscience 2015., Chicago, 10/17-21, 2015

Ryo Fukumori, Takeshi Takarada, Yukio Yoneda., A role of mitochondrial uncoupling protein-2 in NMDA neuroxicity., 11th Biennial Meeting of APSN and 55th Meeting of JSN., Kobe, 9/30-10/2, 2012

Ryo Fukumori, Takeshi Takarada and Yukio Yoneda., Properties of acquired NMDAR channels expressed in HEK293 cells., ISN-ESN-2011., Athens, 8/28-9/1, 2011

Ryo Fukumori, Noritaka Nakamichi, Yuki Kambe, Takeshi Takarada and Yukio Yoneda., Acquired NMDA channels artificially expressed in HEK293 cells., CINP 2010 World Congress., Hong Kong, 6/6-10, 2010

Ryo Fukumori, Yuki Kambe, Takeshi Takarada, Yukio Yoneda., NMDA Receptor Channels Artificially Expressed in HEK293 cells., The 1st Meeting of the Asian College of Neuropsychopharmacology (AsCNP)・第19回日本臨床精神神経薬理学会・第39回日本神経精神薬理学会合同年会., Kyoto, 11/13-15, 2009

Ryo Fukumori, Noritaka Nakamichi, Yuki Kambe, Takeshi Takarada, Yukio Yoneda., Properties of acquired NMDA channels in HEK293 cells., The 22nd Biennial Meeting of the ISN/APSN Joint Meeting., Busan, 8/23-28., 2009

＜国内学会発表（筆頭発表者のみ、他33報）＞

福森良、太田賢作、山本経之、山口拓, メタンフェタミン退薬後に発現するPrepulse inhibition障害に対するカンナビノイドCB1受容体拮抗薬の効果, 第50回日本神経精神薬理学会, 仙台（リモート）, 10/21-23, 2020

福森良、太田賢作、山本経之、山口拓, メタンフェタミン退薬時に発現する感覚情報処理機能障害におけるカンナビノイドCB1受容体の関与, 第36回日本薬学会九州支部大会, 長崎, 11/16-17, 2019

福森良、太田賢作、山本経之、山口拓, メタンフェタミン退薬後の認知機能障害発現における内因性カンナビノイドシステムの関与, 第49回日本神経精神薬理学会, 福岡, 10/12-13, 2019

福森良、山本経之、山口拓, メタンフェタミン反復投与後の退薬時に発現する認知機能障害におけるカンナビノイドCB1受容体の関与, 第71回日本薬理学会西南部会, 福岡, 11/17, 2018

福森良、山本経之、山口拓, メタンフェタミン反復投与後の退薬時に発現するPrepulse inhibition障害におけるカンナビノイドCB1受容体の関与, 第70回日本薬理学会西南部会, 鹿児島, 11/18, 2017

福森良、山田啓史、山本経之、山口拓, メタンフェタミン慢性投与後の認知機能障害発現における内在性カンナビノイドシステムの関与, 第89回日本薬理学会年会, 横浜, 3/9-11, 2016