Professor

KOJIMA Naoto

Published Papers

Chemical structures of polyketides and alkaloids isolated from a culture of fungus Curvularia moringae

Takahiro Matsumoto,Miho Hamai,Yayako Inui,Tomoe Ohta,Tatsusada Yoshida,Naoto Kojima,Hayato Yoshikawa,Raku Kutose,Shiori Ando,Tetsushi Watanabe

Fitoterapia 2024-12

Targeting Oxidative Phosphorylation with a Novel Thiophene Carboxamide Increases the Efficacy of Imatinib against Leukemic Stem Cells in Chronic Myeloid Leukemia

Kana Kusaba,Tatsuro Watanabe,Keisuke Kidoguchi,Yuta Yamamoto,Ayaka Tomoda,Toshimi Hoshiko,Naoto Kojima,Susumu Nakata,Shinya Kimura

2024-10-15

Structure–activity relationships study of N-ethylene glycol-comprising alkyl heterocyclic carboxamides against A549 lung cancer cells

Kaito Ohta,Hiromi Ii,Mei Takahashi,Chiami Moyama,Shota Ando,Masaya Mori,Maho Masuda,Hisanori Nambu,Susumu Nakata,Naoto Kojima

Future Medicinal Chemistry 2024-09-19

Regioselective SmI₂-Mediated Radical ipso-Substitution Cyclization for the Construction of Pyrrolophenanthridinone Skeletons: The Synthesis of Amaryllidaceae Alkaloids

Hiroki Iwasaki,Mari Ikemoto,Haruka Shibata,Yuka Shima,Erina Himeno,Naoto Kojima,Masayuki Yamashita,Hisanori Nambu

Chemical and Pharmaceutical Bulletin 2023-07-01

Thiophene Carboxamide Analogs with Long Alkyl Chains Comprising Ethylene Glycol Units Inhibit Glioblastoma Cell Proliferation by Activating AMPK

Kaito Ohta,Hiromi Ii,Chiami Moyama,Shota Ando,Hisanori Nambu,Susumu Nakata,Naoto Kojima

Journal of Medicinal Chemistry 2023-04-28

Facile synthesis of 5-alkoxy-4-aryltetrahydrofuran-2-one using hypervalent iodine reagents

Takuya Matsumoto,Saya Okazaki,Shui Aoki,Aya Niki,Hiroki Iwasaki,Minoru Ozeki,Masayuki Yamashita,Naoto Kojima,Ikuo Kawasaki

Tetrahedron Letters 2023-03

Synthesis of Acetogenin Analogs Comprising Pyrimidine Moieties Linked by Amine Bonds and Their Inhibitory Activity against Human Cancer Cell Lines

Hiroyuki Hosomi,Akinobu Akatsuka,Shingo Dan,Hiroki Iwasaki,Hisanori Nambu,Naoto Kojima

Chemical and Pharmaceutical Bulletin 2022-11-01

JCI‑20679 suppresses the proliferation of glioblastoma stem cells by activating AMPK and decreasing NFATc2 expression levels

Shota Ando,Naoto Kojima,Chiami Moyama,Mitsugu Fujita,Kaito Ohta,Hiromi Ii,Susumu Nakata

Molecular Medicine Reports 2022-05-27

Structure–antitumor activity relationship of hybrid acetogenins focusing on connecting groups between heterocycles and the linker moiety

Kaito Ohta,Tetsuya Fushimi,Mutsumi Okamura,Akinobu Akatsuka,Shingo Dan,Hiroki Iwasaki,Masayuki Yamashita,Naoto Kojima

RSC Advances 2022-05

JCI-20679 suppresses autophagy and enhances temozolomide-mediated growth inhibition of glioblastoma cells

Shota Ando,Chiami Moyama,Naoto Kojima,Mitsugu Fujita,Kaito Ohta,Yukina Kohno,Hiromi Ii,Susumu Nakata

Biochemical and Biophysical Research Communications 2022-02

MISC

The acetogenin analog JCI-20679 inhibits glioblastoma stem cell proliferation via AMPK activation and NFAT1 suppression.

安藤翔太,小島直人,茂山千愛美,藤田貢,飯居宏美,中田晋

日本薬学会年会要旨集(Web) 2021-10