Professor

KOJIMA Naoto

Published Papers

Regioselective SmI₂-Mediated Radical ipso-Substitution Cyclization for the Construction of Pyrrolophenanthridinone Skeletons: The Synthesis of Amaryllidaceae Alkaloids

Hiroki Iwasaki,Mari Ikemoto,Haruka Shibata,Yuka Shima,Erina Himeno,Naoto Kojima,Masayuki Yamashita,Hisanori Nambu

Chemical and Pharmaceutical Bulletin 2023-07-01

Thiophene Carboxamide Analogs with Long Alkyl Chains Comprising Ethylene Glycol Units Inhibit Glioblastoma Cell Proliferation by Activating AMPK

Kaito Ohta,Hiromi Ii,Chiami Moyama,Shota Ando,Hisanori Nambu,Susumu Nakata,Naoto Kojima

Journal of Medicinal Chemistry 2023-04-28

Facile synthesis of 5-alkoxy-4-aryltetrahydrofuran-2-one using hypervalent iodine reagents

Takuya Matsumoto,Saya Okazaki,Shui Aoki,Aya Niki,Hiroki Iwasaki,Minoru Ozeki,Masayuki Yamashita,Naoto Kojima,Ikuo Kawasaki

Tetrahedron Letters 2023-03

Synthesis of Acetogenin Analogs Comprising Pyrimidine Moieties Linked by Amine Bonds and Their Inhibitory Activity against Human Cancer Cell Lines

Hiroyuki Hosomi,Akinobu Akatsuka,Shingo Dan,Hiroki Iwasaki,Hisanori Nambu,Naoto Kojima

Chemical and Pharmaceutical Bulletin 2022-11-01

JCI‑20679 suppresses the proliferation of glioblastoma stem cells by activating AMPK and decreasing NFATc2 expression levels

Shota Ando,Naoto Kojima,Chiami Moyama,Mitsugu Fujita,Kaito Ohta,Hiromi Ii,Susumu Nakata

Molecular Medicine Reports 2022-05-27

Structure–antitumor activity relationship of hybrid acetogenins focusing on connecting groups between heterocycles and the linker moiety

Kaito Ohta,Tetsuya Fushimi,Mutsumi Okamura,Akinobu Akatsuka,Shingo Dan,Hiroki Iwasaki,Masayuki Yamashita,Naoto Kojima

RSC Advances 2022-05

JCI-20679 suppresses autophagy and enhances temozolomide-mediated growth inhibition of glioblastoma cells

Shota Ando,Chiami Moyama,Naoto Kojima,Mitsugu Fujita,Kaito Ohta,Yukina Kohno,Hiromi Ii,Susumu Nakata

Biochemical and Biophysical Research Communications 2022-02

Construction of sulfur-containing compounds with anti-cancer stem cell activity using thioacrolein derived from garlic based on nature-inspired scaffolds

Taichi Yoneda,Naoto Kojima,Takahiro Matsumoto,Daisuke Imahori,Tomoe Ohta,Tasusada Yoshida,Tetsushi Watanabe,Hisashi Matsuda,Seikou Nakamura

Organic & Biomolecular Chemistry 2022-01

Chemical structures and induction of cell death via heat shock protein inhibition of the prenylated phloroglucinol derivatives isolated from Hypericum erectum

Takahiro Μatsumoto,Daisuke Imahori,Erika Ohnishi,Masaya Okayama,Takahiro Kitagawa,Tomoe Ohta,Tatsusada Yoshida,Naoto Kojima,Masayuki Yamashita,Tetsushi Watanabe

Fitoterapia 2022-01

MISC

The acetogenin analog JCI-20679 inhibits glioblastoma stem cell proliferation via AMPK activation and NFAT1 suppression.

安藤翔太,小島直人,茂山千愛美,藤田貢,飯居宏美,中田晋

日本薬学会年会要旨集(Web) 2021-10