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Nagasaki International University

Academic Research Staff and Principal AchievementAchievement

Professor

KOJIMA Naoto

KOJIMA Naoto

Published Papers

Regioselective SmI2-Mediated Radical ipso-Substitution Cyclization for the Construction of Pyrrolophenanthridinone Skeletons: The Synthesis of Amaryllidaceae Alkaloids

Hiroki Iwasaki,Mari Ikemoto,Haruka Shibata,Yuka Shima,Erina Himeno,Naoto Kojima,Masayuki Yamashita,Hisanori Nambu

Chemical and Pharmaceutical Bulletin 2023-07-01


Thiophene Carboxamide Analogs with Long Alkyl Chains Comprising Ethylene Glycol Units Inhibit Glioblastoma Cell Proliferation by Activating AMPK

Kaito Ohta,Hiromi Ii,Chiami Moyama,Shota Ando,Hisanori Nambu,Susumu Nakata,Naoto Kojima

Journal of Medicinal Chemistry 2023-04-28


Facile synthesis of 5-alkoxy-4-aryltetrahydrofuran-2-one using hypervalent iodine reagents

Takuya Matsumoto,Saya Okazaki,Shui Aoki,Aya Niki,Hiroki Iwasaki,Minoru Ozeki,Masayuki Yamashita,Naoto Kojima,Ikuo Kawasaki

Tetrahedron Letters 2023-03


Synthesis of Acetogenin Analogs Comprising Pyrimidine Moieties Linked by Amine Bonds and Their Inhibitory Activity against Human Cancer Cell Lines

Hiroyuki Hosomi,Akinobu Akatsuka,Shingo Dan,Hiroki Iwasaki,Hisanori Nambu,Naoto Kojima

Chemical and Pharmaceutical Bulletin 2022-11-01


JCI‑20679 suppresses the proliferation of glioblastoma stem cells by activating AMPK and decreasing NFATc2 expression levels

Shota Ando,Naoto Kojima,Chiami Moyama,Mitsugu Fujita,Kaito Ohta,Hiromi Ii,Susumu Nakata

Molecular Medicine Reports 2022-05-27


Structure–antitumor activity relationship of hybrid acetogenins focusing on connecting groups between heterocycles and the linker moiety

Kaito Ohta,Tetsuya Fushimi,Mutsumi Okamura,Akinobu Akatsuka,Shingo Dan,Hiroki Iwasaki,Masayuki Yamashita,Naoto Kojima

RSC Advances 2022-05


JCI-20679 suppresses autophagy and enhances temozolomide-mediated growth inhibition of glioblastoma cells

Shota Ando,Chiami Moyama,Naoto Kojima,Mitsugu Fujita,Kaito Ohta,Yukina Kohno,Hiromi Ii,Susumu Nakata

Biochemical and Biophysical Research Communications 2022-02


Construction of sulfur-containing compounds with anti-cancer stem cell activity using thioacrolein derived from garlic based on nature-inspired scaffolds

Taichi Yoneda,Naoto Kojima,Takahiro Matsumoto,Daisuke Imahori,Tomoe Ohta,Tasusada Yoshida,Tetsushi Watanabe,Hisashi Matsuda,Seikou Nakamura

Organic & Biomolecular Chemistry 2022-01


Chemical structures and induction of cell death via heat shock protein inhibition of the prenylated phloroglucinol derivatives isolated from Hypericum erectum

Takahiro Μatsumoto,Daisuke Imahori,Erika Ohnishi,Masaya Okayama,Takahiro Kitagawa,Tomoe Ohta,Tatsusada Yoshida,Naoto Kojima,Masayuki Yamashita,Tetsushi Watanabe

Fitoterapia 2022-01


Structure-activity relationships of thiophene carboxamide annonaceous acetogenin analogs: Shortening the alkyl chain in the tail part significantly affects their growth inhibitory activity against human cancer cell lines

Kaito Ohta,Akinobu Akatsuka,Shingo Dan,Hiroki Iwasaki,Masayuki Yamashita,Naoto Kojima

Chem. Pharm. Bull. 2021-10


MISC

Novel AMPK activators inhibiting mitochondrial complex I that attack glioblastoma, and colon/lung cancer

中田晋,小島直人

日本癌学会学術総会抄録集(Web) 2023


Synthesis and Antitumor Activity of Novel Analog of Acetogenin Thiophene Analog with Triethylene Glycol in place of THF Moiety

大田海斗,藤井真人,茂山千愛美,飯居宏美,中田晋,岩崎宏樹,山下正行,南部寿則,小島直人

日本薬学会年会要旨集(Web) 2023


Synthesis of Acetogenin Thiophene Analogs Conformationally Fixed by Cyclopentane Rings and Clarification Research of Molecular Mechanism

細見紘幸,小柴佐和子,松本卓也,安藤翔太,茂山千愛美,飯居宏美,中田晋,岩崎宏樹,山下正行,南部寿則,小島直人

日本薬学会年会要旨集(Web) 2023


Synthesis of Thiophene Carboxamides with Alkyl Chain Comprising Ethylene Glycol Units, and Their Growth Inhibitory Activity against Glioblastoma Stem Cells

高橋達哉,大田海斗,竜石侑璃,安藤翔太,茂山千愛美,飯居宏美,中田晋,岩崎宏樹,山下正行,南部寿則,小島直人

日本薬学会年会要旨集(Web) 2023


Synthesis and Evaluation of Antitumor Effects of Thiophene Carboxamide Analogs toward Development of the Antitumor Agents for Glioblastoma

大田海斗,小島直人,中田晋

日本がん分子標的治療学会学術集会プログラム・抄録集 2023


The acetogenin analog JCI-20679 inhibits glioblastoma stem cell proliferation via AMPK activation and NFAT1 suppression.

安藤翔太,小島直人,茂山千愛美,藤田貢,飯居宏美,中田晋

日本薬学会年会要旨集(Web) 2021-10


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