Professor

SASAKI Shigeki

Published Papers

Site-specific acetyl modification of 2'-OH of RNA by an oligonucleotide acetylating reagent.

Hirotaka Murase,Mio Eto,Jeongsu Lee,Yosuke Taniguchi,Shuhei Imoto,Shigeki Sasaki

Chemical communications (Cambridge, England) 2024-11-12

Design and synthesis of an environment-sensitive 3-methyleneisoindolin-1-one fluorophore for labeling DNA-interacting proteins.

Mariko Aso,Chiyoe Ohta,Yixuan Liu,Kaori Sasaki-Tabata,Yukiko Abe-Sadamatsu,Chiemi Gatanaga,Yichun Wang,Yang Pei,Guosheng Gao,Tsutomu Katayama,Yosuke Taniguchi,Shigeki Sasaki

Organic & biomolecular chemistry 2024-09-11

The selective chemical modification of the 6-amino group of adenosine of the premature termination codon induces readthrough to produce full-length peptide in the reconstituted E. Coli translation system

Hirotaka Murase,Jeongsu Lee,Norihiro Togo,Yosuke Taniguchi,Shigeki Sasaki

Bioorganic & Medicinal Chemistry 2024-09

Novel strategy for activating gene expression through triplex DNA formation targeting epigenetically suppressed genes.

Ryotaro Notomi,Shigeki Sasaki,Yosuke Taniguchi

RSC chemical biology 2024-08-28

Manipulating nucleic acids - regulation of gene expression through higher order structure and chemical modification

Shigeki Sasaki,Hirotaka Murase

Drug Delivery System 2024-01-25

Development of an Artificial Nucleic Acid Skeleton Allowing for Unnatural-Type Triplex DNA Formation with Duplex DNA Having a TA Inversion Site

Akihiro Ito,Lei Wang,Ryotaro Notomi,Shigeki Sasaki,Yosuke Taniguchi

CHEMICAL & PHARMACEUTICAL BULLETIN 2024-01

Post-Synthetic Modification of Triplex-Forming Oligonucleotides Containing 2-Aminoethyl-2′-Deoxynebularine Derivatives

Ryotaro Notomi,Shigeki Sasaki,Yosuke Taniguchi

CURRENT PROTOCOLS 2023-10

Inhibition of transcription and antiproliferative effects in a cancer cell line using antigene oligonucleotides containing artificial nucleoside analogues.

Lei Wang,Ryotaro Notomi,Shigeki Sasaki,Yosuke Taniguchi

RSC medicinal chemistry 2023-08-16

Site-Specific Tritium Labeling at the Predefined Internal Position of the Chemically-Modified RNA

Hirotaka Murase,Jeongsu Lee,Yosuke Taniguchi,Shigeki Sasaki

Chemical and Pharmaceutical Bulletin 2023-01-01

Recognition of 5-methyl-CG and CG base pairs in duplex DNA with high stability using antiparallel-type triplex-forming oligonucleotides with 2-guanidinoethyl-2'-deoxynebularine.

Ryotaro Notomi,Shigeki Sasaki,Yosuke Taniguchi

Nucleic acids research 2022-12-01

MISC

The Development of Non-natural Type Nucleoside to Stabilize Triplex DNA Formation against CG and TA Inversion Site

Lei Wang,Yong Ling,Yan Tian,Xiao Wang,Shigeki Sasaki,Yosuke Taniguchi

CURRENT MEDICINAL CHEMISTRY 2024

Adenosine-1,3-diazaphenoxazine Derivative for Selective Base Pair Formation with 8-Oxo-2 '-deoxyguanosine in DNA (vol 133, pg 7272, 2011)

Yosuke Taniguchi,Ryota Kawaguchi,Shigeki Sasaki

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2011-07

Synthesis of Reactive Oligonucleotides for Gene Targeting and Their Application to Gene Expression Regulation

Nagatsugi, F,Sasaki, S

Bulletin of the Chemical Society of Japan 2010-07

A new usage of functionalized oligodeoxynucleotide probe for site-specific modification of a guanine base within RNA

Kazumitsu Onizuka,Yosuke Taniguchi,Shigeki Sasaki

NUCLEIC ACIDS RESEARCH 2010-03

Recognition of CG interrupting site by W-shaped nucleoside analogs (WNA) having the pyrazole ring in an anti-parallel triplex DNA

Yosuke Taniguchi,Yuko Uchida,Tomoko Takaki,Eriko Aoki,Shigeki Sasaki

BIOORGANIC & MEDICINAL CHEMISTRY 2009-10

Site-Specific Covalent Modification of RNA Guided by Functionality-Transfer Oligodeoxynucleotides

Kazumitsu Onizuka,Yosuke Taniguchi,Shigeki Sasaki

BIOCONJUGATE CHEMISTRY 2009-04

Incorporation of an inducible nucleotide analog into DNA by DNA polymerases

Md. Monsur Ali,Shuhei Imoto,Yingfu Li,Shigeki Sasaki,Fumi Nagatsugi

BIOORGANIC & MEDICINAL CHEMISTRY 2009-04

Selective fluorescence quenching of the 8-oxoG-clamp by 8-oxodeoxyguanosine in ODN

Tamer Nasr,Zhichun Li,Osamu Nakagawa,Yosuke Taniguchi,Sayaka Ono,Shigeki Sasaki

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2009-02