Professor

NISHIOKU Tsuyoshi

Published Papers

Nalmefene attenuates reinstatement of methamphetamine-seeking behavior in rats through group II metabotropic glutamate receptors (mGluR2/3)

Yoko Nawata,Rina Ooishi,Tsuyoshi Nishioku,Taku Yamaguchi

Behavioural Brain Research 2024-01

Dimethyl fumarate prevents osteoclastogenesis by decreasing NFATc1 expression, inhibiting of erk and p38 MAPK phosphorylation, and suppressing of HMGB1 release.

Tsuyoshi Nishioku,Momomi Kawamoto,Ryuya Okizono,Eiko Sakai,Kuniaki Okamoto,Takayuki Tsukuba

Biochemical and biophysical research communications 2020-09-17

(-)-Epigallocatechin-3-gallate inhibits RANKL-induced osteoclastogenesis via downregulation of NFATc1 and suppression of HO-1-HMGB1-RAGE pathway.

Tsuyoshi Nishioku,Toshiki Kubo,Tsukushi Kamada,Kuniaki Okamoto,Takayuki Tsukuba,Takuhiro Uto,Yukihiro Shoyama

Biomedical research (Tokyo, Japan) 2020

Berberine Induces Apoptotic Cell Death via Activation of Caspase-3 and -8 in HL-60 Human Leukemia Cells: Nuclear Localization and Structure-Activity Relationships.

Shinya Okubo,Takuhiro Uto,Aya Goto,Hiroyuki Tanaka,Tsuyoshi Nishioku,Katsushi Yamada,Yukihiro Shoyama

The American journal of Chinese medicine 2017

CD147 promotes the formation of functional osteoclasts through NFATc1 signalling.

Tsuyoshi Nishioku,Mariko Terasawa,Misaki Baba,Atsushi Yamauchi,Yasufumi Kataoka

Biochemical and biophysical research communications 2016-04-29

Paracellular barrier and tight junction protein expression in the immortalized brain endothelial cell lines bEND.3, bEND.5 and mouse brain endothelial cell 4.

Watanabe T,Dohgu S,Takata F,Nishioku T,Nakashima A,Futagami K,Yamauchi A,Kataoka Y

Biol Pharm Bull. 2013

BMP4 is increased in the aortas of diabetic ApoE knockout mice and enhances uptake of oxidized low density lipoprotein into peritoneal macrophages.

Koga M,Yamauchi A,Kanaoka Y,Jige R,Tsukamoto A,Teshima N,Nishioku T,Kataoka Y

J Inflamm (Lond). 2013

Lipopolysaccharide-activated microglia lower P-glycoprotein function in brain microvascular endothelial cells.

Matsumoto J,Dohgu S,Takata F,Nishioku T,Sumi N,Machida T,Takahashi H,Yamauchi A,Kataoka Y

Neurosci Lett. 2012

Atorvastatin stimulates neuroblastoma cells to induce neurite outgrowth by increasing cellular prion protein expression.

Watanabe T,Yasutaka Y,Nishioku T,Nakashima A,Futagami K,Yamauchi A,Kataoka Y

Neurosci Lett. 2012

Cyclophilin A secreted from fibroblast-like synoviocytes is involved in the induction of CD147 expression in macrophages of mice with collagen-induced arthritis.

Nishioku T,Dohgu S,Koga M,Machida T,Watanabe T,Miura T,Tsumagari K,Terasawa M,Yamauchi A,Kataoka Y

J Inflamm (Lond). 2012

MISC

S100A4 is a causative factor for disruption of the blood-brain barrier in collagen-induced arthritic mice

Tsuyoshi Nishioku,Atsushi Yamauchi,Yasufumi Kataoka

JOURNAL OF PHARMACOLOGICAL SCIENCES 2012

BBB hyperpermeability to sodium fluorescein in obese mice with impaired glucose tolerance induced by high-fat diet

Fuyuko Takata,Shinya Dohgu,Takashi Obara,Junichi Matsumoto,Tsuyoshi Nishioku,Atsushi Yamauchi,Hideki Shuto,Yasufumi Kataoka

JOURNAL OF PHARMACOLOGICAL SCIENCES 2010

Reactive oxygen species (ROS)-mediated regulation of MMP-9 expression in the brain pericytes

Kousuke Matsumoto,Shinya Dohgu,Fuyuko Takata,Junichi Matsumoto,Natsuko Ichiki,Sayaka Tao,Haruki Miyaji,Tsuyoshi Nishioku,Hideki Shuto,Atsushi Yamauchi,Yasufumi Kataoka

JOURNAL OF PHARMACOLOGICAL SCIENCES 2010

Functional impact of RIMs on gating of voltage-dependent Ca2+channels

Junichi Matsumoto,Noriko Sumi,Tsuyoshi Nishioku,Shinya Dohgu,Shinsuke Nakagawa,Atsushi Yamauchi,Hideki Shuto,Masami Niwa,Yasufumi Kataoka

JOURNAL OF PHARMACOLOGICAL SCIENCES 2009

Oncostatin M induces functional and structural impairment of blood-brain barriers comprised of rat brain capillary endothelial cells

Tomoya Wakigawa,Fuyuko Takata,Shinya Dohgu,Eriko Harada,Kousuke Matumoto,Takasi Obara,Yasufumi Kataoka

JOURNAL OF PHARMACOLOGICAL SCIENCES 2009

アドレノメデュリンによる脳血管周皮細胞ペリサイトの弛緩作用 脳微細循環調節機構の解明を目指して

原田 枝理子,高田 芙友子,湧川 朝也,西奥 剛,角 典子,児玉 耕太,山内 淳史,中川 慎介,首藤 英樹,丹羽 正美,片岡 泰文

日本薬理学雑誌 2008-03

Involvement of the activated microglia in the induction of blood-brain barrier dysfunction

Noriko Sumi,Tsuyoshi Nishioku,Kotoe Asano,Junichi Matsumoto,Shinsuke Nakagawa,Atsushi Yamauchi,Hideki Shuto,Masami Niwa,Yasufumi Kataoka

JOURNAL OF PHARMACOLOGICAL SCIENCES 2008

Time-course of morphological alterations of pericytes in the blood-brain barrier disruption

Naoko Ishikawa,Tsuyoshi Nishioku,Noriko Sumi,Hiromi Nakanishi,Atsushi Yamauchi,Shinsuke Nakagawa,Hideki Shuto,Masami Niwa,Yasufumi Kataoka

JOURNAL OF PHARMACOLOGICAL SCIENCES 2008

Immunohistochemical analysis of pericytes in the blood-brain barrier disruption

Tomoaki Eto,Tsuyoshi Nishioku,Fuyuko Takata,Atsushi Yamauchi,Shinnsuke Nakagawa,Hideki Shuto,Masami Niwa,Yasufumi Kataoka

JOURNAL OF PHARMACOLOGICAL SCIENCES 2007

Protective effect of adrenomedullin on lipopolysaccharide-induced blood-brain barrier dysfunction

Noriko Sumi,Tsuyoshi Nishioku,Fuyuko Takata,Atsushi Yamauchi,Shinsuke Nakagawa,Maria A. Deli,Hideki Shuto,Masami Niwa,Yasufumi Kataoka

JOURNAL OF PHARMACOLOGICAL SCIENCES 2007